Our lab is directly involved in a number of preclinical and clinical trials.
The hematopoietic microenvironment is critical for the self-renewal, proliferation, and differentiation of pluripotent hematopoietic stem cells.
In collaboration with David Lyden (Cornell University Weill Medical College), we have discovered that nonmalignant bone marrow cells establish "cellular bookmarks" in target organs that guide cance
Development and maintenance of the haematopoietic system relies on a scant number of self-renewing haematopoietic stem cells (HSCs) residing in the adult bone marrow and representing the top of a c
Despite initial enthusiasm to use adult bone marrow stem cells for organ regeneration, evidence suggests that adult bone marrow contains limited numbers of organ-specific stem cells.
Stem cells derived from adult tissues are endowed with the unique capacity to regenerate functional organs.